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Myocardial Biopsy

Definition, Purpose, Precautions, Description, Preparation, Aftercare, Risks

Myocardial biopsy is a procedure wherein a small portion of tissue is removed from the heart muscle for testing. This test is also known as endomyocardial biopsy.


The main reason for a biopsy is to secure tissue samples that will be useful in the diagnosis, treatment, and

Once the catheter is threaded up into the heart, the surgeon will take several small samples of muscle for laboratory analysis. (Custom Medical Stock Photo. Reproduced by permission.) Once the catheter is threaded up into the heart, the surgeon will take several small samples of muscle for laboratory analysis. (Custom Medical Stock Photo. Reproduced by permission.)

care of heart muscle disorders. The test is also used to detect rejection after a heart transplantation procedure.


This procedure is not used when the patient is taking blood-thinning medication (anticoagulant therapy). It should not be done when the patient has leukemia and aplastic anemia or if there is a blood clot on the interior wall of the heart.


A long, flexible tube, called a catheter, is inserted into a vein and threaded up into the heart. The doctor can guide the catheter by watching its movement on a TV monitor showing an x-ray image of the area. The tip of the catheter is fitted with tiny jaws that the doctor can open and close. Once the catheter is in place, the doctor will take several small snips of muscle for microscopic examination.


Preparation for myocardial biopsy is quite extensive. The patient will be asked not to eat for several hours before the procedure. A technician will shave the hair from the area of the incision and will also insert an intravenous line in the arm. The patient will be given a sedative to relax but will not be fully anesthetized. The patient will be connected to an electrocardiograph (ECG) to monitor the heart, and a blood-pressure cuff will be placed. Finally, the patient will be covered with sterile drapes, so that the area of the biopsy is kept free of germs. The cardiologist will numb the area where the catheter will be inserted.


At the end of the biopsy, the catheter will be removed and pressure will be applied at the site where it entered the blood vessel in order to encourage healing. The patient will then be taken to the recovery room. It is advisable to remain flat and not to move about for 6-8 hours. After that time, most people begin walking around. Swelling and bruising at the puncture site are common and usually go away without need for further attention.


The risks involved with myocardial biopsy are small because the patient is monitored closely and attended by well-trained staff. Racing of the heart (palpitations) and quivering of the heart muscles (atrial fibrillation) are both possible during the procedure.



McGoon, Michael D., ed. Mayo Clinic Heart Book: The Ultimate Guide to Heart Health. New York: William Morrow and Co., Inc., 1993.


American Heart Association. 7320 Greenville Ave. Dallas, TX 75231. (214) 373-6300. <http://www.americanheart.org>.

Dorothy Elinor Stonely


Anticoagulant—Medication that thins the blood and slows clot formation.

Aplastic anemia—A greatly decreased production of all of the formed elements of the blood caused by a failure of the cell-generating capacity of the bone marrow.

Electrocardiography—A test that uses electrodes attached to the chest with an adhesive gel to transmit the electrical impulses of the heart muscle to a recording device.

Leukemia—A disease characterized by an increasing number of abnormal cells in the blood.

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